(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate

Base Information

Chemical Name:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate
CAS No.:168104-59-4
Molecular Formula:C₃₁H₃₅FO₃
Molecular Weight:474.616
Hs Code.:

Synonyms:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate

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Chemical Property of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate

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Technology Process of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate

There total 4 articles about (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65253-04-5
(-)-8-phenylmenthol

: 168104-59-4
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) α,α-dichloromethyl methyl ether, 2.) Et3N / 1.) 50 deg C, 2 h, 2.) CH2Cl2, RT, overnight

2: tetrahydrofuran / a) dry ice/acetone temp., 2 h, b) RT, overnight

With Dichloromethyl methyl ether; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00010a016

Reference yield:

: 76590-57-3
ethyl 2-[4-(bromomethyl)phenyl]-2-oxoacetate

: 168104-59-4
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / Me₄NHF₂ / acetonitrile / 1.58 h / Heating

2: 75 percent / 2 N aq. NaOH / 1 h

3: 1.) α,α-dichloromethyl methyl ether, 2.) Et3N / 1.) 50 deg C, 2 h, 2.) CH2Cl2, RT, overnight

4: tetrahydrofuran / a) dry ice/acetone temp., 2 h, b) RT, overnight

With sodium hydroxide; Dichloromethyl methyl ether; tetramethylammonium hydrogen difluoride; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00010a016

Reference yield:

: 114996-72-4
(4-fluromethyl)benzoylformic acid

: 168104-59-4
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) α,α-dichloromethyl methyl ether, 2.) Et3N / 1.) 50 deg C, 2 h, 2.) CH2Cl2, RT, overnight

2: tetrahydrofuran / a) dry ice/acetone temp., 2 h, b) RT, overnight

With Dichloromethyl methyl ether; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00010a016