(1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride

Base Information

Chemical Name:(1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride
CAS No.:130647-29-9
Molecular Formula:C₁₆H₂₉NOSi*ClH
Molecular Weight:315.959
Hs Code.:

Synonyms:(1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride

Chemical Property:

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Technology Process of (1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride

There total 1 articles about (1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 50-98-6
ephedrine hydrochloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130647-29-9
(1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 70 ℃; for 24h; Inert atmosphere;
DOI:10.1055/s-0036-1588523

Reference yield:

: 25468-31-9
N-methyl-N-methylenemethanaminium 2,2,2-trifluoroacetate

: 130647-29-9
(1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride

: C₁₉H₃₆N₂OSi

Guidance literature:: (1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride; With methylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

N-methyl-N-methylenemethanaminium 2,2,2-trifluoroacetate; In tetrahydrofuran; dichloromethane; at -20 ℃; for 0.75h; Schlenk technique; Inert atmosphere;
DOI:10.1055/s-0036-1588523

Reference yield:

: 130647-29-9
(1R,2S)-(-)-2-(methylamino)-1-phenyl-1-<(t-butyldimethylsilyl)oxy>-propane hydrochloride

: (1R,2S)-2-(methyl(3-(trifluoromethyl)phenethyl)amino)-1-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: methylmagnesium chloride / tetrahydrofuran / 0.5 h / -20 °C / Schlenk technique; Inert atmosphere

1.2: 0.75 h / -20 °C / Schlenk technique; Inert atmosphere

2.1: trifluoroacetic anhydride / dichloromethane; tetrahydrofuran / 0.25 h / -20 °C / Schlenk technique; Inert atmosphere

3.1: dichloromethane; tetrahydrofuran / -78 - 25 °C / Schlenk technique; Inert atmosphere

4.1: tetrabutyl ammonium fluoride / 12 h / 25 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; methylmagnesium chloride; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0036-1588523