2290-03-1

Upstream product

• 76529-39-0 methyl (phenylseleno)formate 
• 100-63-0 phenylhydrazine 
• 616-38-6 carbonic acid dimethyl ester 
• 59-88-1 phenylhydrazine hydrochloride 
• 79-22-1 methyl chloroformate 
• 55734-39-9 1-(methoxycarbonyloxy)-2,2-bis(trifluoromethyl)aziridine 
• 134920-16-4 N-methoxycarbonyl-3-phenyloxaziridine 
• 62-53-3 aniline 
• 67-56-1 methanol 
• 940-38-5 phenylcarbamoyl azide 

Downstream Products

• 67-56-1 methanol 
• 52353-62-5 4-anilino-1-phenyl-1,2,4-triazolidine-3,5-dione 
• 74692-72-1 Phenyl-ONN-azoxymethylester 
• 100-63-0 phenylhydrazine 
• 2207-96-7 methyl 2-phenyldiazene-1-carboxylate 

Relevant academic research and scientific papers

Phosphine-Catalyzed Cascade Annulation of MBH Carbonates and Diazenes: Synthesis of Hexahydrocyclopenta[c]pyrazole Derivatives

A phosphine-catalyzed cascade annulation of Morita-Baylis-Hillman (MBH) carbonates and diazenes was achieved, giving tetrahydropyrazole-fused heterocycles bearing two five-membered rings in moderate to excellent yields. The reaction underwent an unprecedented reaction mode of MBH carbonates, in which two molecules of MBH carbonates were fully merged into the ring system.

HYDRAZIDE DERIVATIVES AND THEIR SPECIFIC USE AS ANTIBACTERIAL AGENTS BY CONTROLLING ACINETOBACTER BAUMANNII BACTERIUM

The present invention relates to compounds of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, their use as a drug, in particular as antibacterial agent, notablyforpreventingand/or treating disorders associa

Phosphine-Catalyzed Asymmetric Cycloaddition Reaction of Diazenes: Enantioselective Synthesis of Chiral Dihydropyrazoles

Although carbon-carbon, carbon-nitrogen, and carbon-oxygen double bonds or their combinations have extensively been applied in phosphine-catalyzed asymmetric cycloaddition, a nitrogen-nitrogen double bond has never been investigated in chiral phosphine ca

Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones

We report here the reactivity and selectivity of three 5-Methoxy-N-3-Phenyl substituted-1,3,4-Oxadiazol-2(3H)-ones (MPOX, as well as meta and para-PhenoxyPhenyl derivatives, i.e. MmPPOX and MpPPOX) with respect to the inhibition of mammalian digestive lip

Formation of cinnoline derivatives by a gold(I)-catalyzed hydroarylation of N-propargyl-N′-arylhydrazines

A study concerning the gold(I)-catalyzed hydroarylation of N-propargyl-N′-arylhydrazinecarboxylic acid methyl esters is described. The use of the gold complex [XPhosAu(NCCH3)SbF6] as the catalyst in refluxing nitromethane allows the

Reaction of the ambident electrophile dimethyl carbonate with the ambident nucleophile phenylhydrazine

(Chemical Equation Presented) To explore the ambident electrophilic reactivity of dimethyl carbonate (DMC), reactions with the ambident nucleophile phenylhydrazine were investigated. When a Broensted base was used, selective carboxymethylation occurred at

N-alkyloxycarbonyl-3-aryloxaziridines: Their preparation, structure, and utilization as electrophilic amination reagents

This paper reports the synthesis of a series of N-protected oxaziridines (N-Moc, Boc, Z or Fmoc) and discusses their ability to deliver their N-alkoxycarbonyl fragment to amines, enolates, sulfur, and phosphorus nucleophiles (electrophilic amination). These oxaziridines are prepared by oxidation of the corresponding imines with oxone or anhydrous MCPBA lithium salt as the source of oxygen. They transfer their N-protected fragment to primary and secondary amines to give protected hydrazines in fair to excelent yield. The nitrogen transfer to free amino acids (in form of their R4N+ salts) is particularly fast, even at low temperature, providing L (or D) N-protected α-hydrazino acids. Enolates are C-aminated to give N-protected α-amino ketones, esters, or amides in modest yield, due to a side aldol reaction of the unreacted enolate with the released benzaldehyde. With tertiary amines (Et3N), sulfides (PhSMe), and phosphines (Ph3P), amination and oxidation proceed in a parallel way; the amount of amination product increases when the temperature is lowered (kinetic control). Some of the factors that can orient the oxaziridine reactivity towards amination or oxidation of nucleophiles are considered.

5-Lipoxygenase inhibitors: Synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones

Synthetic routes were developed to access a variety of novel 1-aryl- 2H,4H-tetrahydro-1,2,4-triazin-3-one analogs which were evaluated as 5- lipoxygenase (5-LO) inhibitors. The parent structure, 1-phenylperhydro- 1,2,4-triazin-3-one (4), was found to be a

N-Amination Using N-Methoxycarbonyl-3-phenyloxaziridine. Direct Access to Chiral Nβ-Protected α-Hydrazinoacids and Carbazates

Primary and secondary amines =NH, including α-aminoacids, can be converted under mild conditions to the corresponding carbazates =N-NH-CO2Me, on reaction with N-methoxycarbonyl-3-phenyloxaziridine 1.

ORGANOSELENIUM COMPOUNDS. IV. METHYL (ARYLSELENO)FORMATES, SYNTHESIS AND PROPERTIES

The synthesis of methyl (arylseleno)formates, based on the reaction of (arylseleno)magnesium bromides with methyl chloroformate, is described.Some characteristics of the methyl (arylseleno)formates are given.