S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate

Base Information

Chemical Name:S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate
CAS No.:1391943-51-3
Molecular Formula:C₂₁H₁₁Cl₂F₄N₃O₂S
Molecular Weight:516.303
Hs Code.:

Synonyms:S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate

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Chemical Property of S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate

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Technology Process of S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate

There total 6 articles about S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1391943-37-5
3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxylic acid

: 5188-07-8
sodium thiomethoxide

: 1391943-51-3
S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate

Guidance literature:: 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxylic acid; With thionyl chloride; for 2h; Reflux;

sodium thiomethoxide; In 1,4-dioxane; for 24h;

Reference yield:

: 1391944-17-4
ethyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxylate

: 1391943-51-3
S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 1 h / Reflux

1.2: pH 2

2.1: thionyl chloride / 2 h / Reflux

2.2: 24 h

With thionyl chloride; water; sodium hydroxide; In ethanol;

Reference yield:

: 4415-09-2
methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

: 1391943-51-3
S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 6 h / Reflux

2.1: dichloromethane / 3 h / 20 °C / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / Reflux

4.1: sodium hydroxide; water / ethanol / Reflux

4.2: pH 1

5.1: thionyl chloride / 2 h / Reflux

5.2: 24 h

With thionyl chloride; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; toluene;