2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide

Base Information

• Chemical Name: 2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide
• CAS No.: 1161355-90-3
• Molecular Formula: C₂₂H₂₂N₂O
• Molecular Weight: 330.429
• Mol file: 1161355-90-3.mol

Synonyms:2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide

Chemical Property of 2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide

There total 8 articles about 2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-bromophenyl)-propionic acid (53086-52-5) → 2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide (1161355-90-3)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h

3: potassium dihydrogenphosphate; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine / water; 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With potassium dihydrogenphosphate; oxalyl dichloride; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.bmcl.2013.09.041

Reference yield:

dihydroxy-methyl-borane (13061-96-6) + 2-(3-bromophenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide → 2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide (1161355-90-3)

Guidance literature:

With potassium dihydrogenphosphate; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmcl.2013.09.041

Reference yield:

4-(2-methylpyridin-4-yl)phenylamine (216059-91-5) + 2-(3-methylphenyl)propanoic acid (73721-06-9,213406-28-1,601472-22-4) → 2-(3-methylphenyl)-N-(4-(2-methyl-4-pyridinyl)phenyl)propanamide (1161355-90-3)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2013.09.041

upstream raw materials:

4-(2-methylpyridin-4-yl)phenylamine

2-(3-methylphenyl)propanoic acid

dihydroxy-methyl-borane

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline