carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester

Base Information

• Chemical Name: carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester
• CAS No.: 606977-36-0
• Molecular Formula: C₃₀H₃₁N₃O₅
• Molecular Weight: 513.593
• Mol file: 606977-36-0.mol

Synonyms:carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester

Chemical Property of carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester

There total 4 articles about carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-1H-indole-4-carboxylic acid methyl ester (1444-12-8) → carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester (606977-36-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 70 percent / 4-tert-butylcatechol / xylene / 3 h / 150 °C

2.1: 61 percent / H₂ / PtO₂ / ethanol / 96 h / 70 °C

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4.1: propan-2-ol / 12 h / 25 °C

4.2: 22 mg / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With lithium aluminium tetrahydride; 4-tert-Butylcatechol; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; isopropyl alcohol; xylene;

DOI:10.1021/ol034407v

Reference yield:

methyl 1-methyl-3-(2-nitroethyl)-4-indolecarboxylate (606977-32-6) → carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester (606977-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 61 percent / H₂ / PtO₂ / ethanol / 96 h / 70 °C

2.1: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

3.1: propan-2-ol / 12 h / 25 °C

3.2: 22 mg / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With lithium aluminium tetrahydride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; isopropyl alcohol;

DOI:10.1021/ol034407v

Reference yield:

2-ethoxycarbonylaminostyrene oxide (123197-70-6) + phenyl chloroformate (1885-14-9) + 1-methyl-1,3,4,5-tetrahydro-1H-azepino[5,4,3-cd]indole (606977-33-7) → carbonic acid 1-(2-ethoxycarbonylamino-phenyl)-2-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester (606977-36-0) + carbonic acid 2-(2-ethoxycarbonylamino-phenyl)-1-(1-methyl-3,4-dihydro-1H,6H-azepino[5,4,3-cd]indol-5-yl)-ethyl ester phenyl ester

Guidance literature:

2-ethoxycarbonylaminostyrene oxide; 1-methyl-1,3,4,5-tetrahydro-1H-azepino[5,4,3-cd]indole; In isopropyl alcohol; at 25 ℃; for 12h;

phenyl chloroformate; With pyridine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1021/ol034407v

upstream raw materials:

2-ethoxycarbonylaminostyrene oxide

phenyl chloroformate

1-methyl-1,3,4,5-tetrahydro-1H-azepino[5,4,3-cd]indole

1-methyl-1H-indole-4-carboxylic acid methyl ester