N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline

Base Information

Chemical Name:N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline
CAS No.:464216-84-0
Molecular Formula:C₂₁H₂₉F₂NO₂Si
Molecular Weight:393.549
Hs Code.:

Synonyms:N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline

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Chemical Property of N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline

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Technology Process of N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline

There total 3 articles about N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 464216-79-3
tert-butyl-[3-(4-iodophenoxy)propoxy]-dimethylsilane

: 464216-84-0
N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline

Guidance literature:: 2,4-difluorophenylamine; tert-butyl-[3-(4-iodophenoxy)propoxy]-dimethylsilane; With 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; for 0.166667h;

With sodium t-butanolate; In toluene; at 90 ℃;
DOI:10.1055/s-2002-32533

Reference yield:

: 540-38-5
p-Iodophenol

: 464216-84-0
N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / K₂CO₃ / dimethylformamide / 20 °C

2.1: imidazole / dimethylformamide

3.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

3.2: 28 percent / t-BuONa / toluene / 90 °C

With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2002-32533

Reference yield:

: 145073-42-3
3-(4-iodophenoxy)propan-1-ol

: 464216-84-0
N-[4-(3-{tert-butyl(dimethyl)silyloxy}propoxy)phenyl]-2,4-difluoroaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: imidazole / dimethylformamide

2.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

2.2: 28 percent / t-BuONa / toluene / 90 °C

With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2002-32533