3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate

Base Information

Chemical Name:3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate
CAS No.:433716-30-4
Molecular Formula:C₄₄H₃₆F₄N₂O₃
Molecular Weight:716.775
Hs Code.:

Synonyms:3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate

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Chemical Property of 3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate

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Technology Process of 3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate

There total 12 articles about 3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 79-41-4,25087-26-7,50867-57-7
poly(methacrylic acid)

: 464216-92-0
3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propan-1-ol

: 433716-30-4
3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1055/s-2002-32533

Reference yield:

: 540-38-5
p-Iodophenol

: 433716-30-4
3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 84 percent / K₂CO₃ / dimethylformamide / 20 °C

2.1: imidazole / dimethylformamide

3.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

3.2: 28 percent / t-BuONa / toluene / 90 °C

4.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

4.2: t-BuONa / toluene / 100 °C

5.1: 5.93 g / Bu₄NF / tetrahydrofuran

6.1: 90 percent / dicyclohexylcarbodiimide; DMAP / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; tetrabutyl ammonium fluoride; potassium carbonate; dicyclohexyl-carbodiimide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2002-32533

Reference yield:

: 92-66-0
4-bromo-1,1'-biphenyl

: 433716-30-4
3-[4-({4'-[2,4-difluoro(3-methylphenyl)anilino][1,1'-biphenyl]-4-yl}-2,4-difluoroanilino)phenoxy]propyl methacrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 77 percent / I₂; aq. HNO₃ / CCl₄ / Heating

2.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

2.2: 63 percent / t-BuONa / toluene / 90 °C

3.1: DPPF / Pd₂(dba)3 / toluene / 0.17 h

3.2: t-BuONa / toluene / 100 °C

4.1: 5.93 g / Bu₄NF / tetrahydrofuran

5.1: 90 percent / dicyclohexylcarbodiimide; DMAP / tetrahydrofuran / 0 - 20 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; tetrabutyl ammonium fluoride; iodine; nitric acid; dicyclohexyl-carbodiimide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; toluene;
DOI:10.1055/s-2002-32533