1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea

Base Information

• Chemical Name: 1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea
• CAS No.: 133979-35-8
• Molecular Formula: C₂₂H₃₀FN₃OS
• Molecular Weight: 403.564

Synonyms:1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea

Chemical Property of 1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea

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Technology Process of 1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea

There total 5 articles about 1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butylamine (75-64-9) + 6-(2-fluoro-phenoxy)-2,4-diisopropyl-3-isothiocyanato-pyridine (133980-76-4) → 1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea (133979-35-8)

Guidance literature:

In toluene; Heating;

DOI:10.1002/ps.2780420402

Reference yield:

2-fluorophenol (367-12-4) → 1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea (133979-35-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylsulfoxide

2.1: 91 percent / H₂ / Ra-Ni / ethanol; tetrahydrofuran / 30 - 35 °C

3.1: Et₃N / pyridine / -10 °C

3.2: DCC / pyridine / 20 °C

4.1: 86 percent / toluene / Heating

With hydrogen; potassium carbonate; triethylamine; Ra-Ni; In tetrahydrofuran; pyridine; ethanol; dimethyl sulfoxide; toluene; 1.1: condensation / 2.1: Reduction / 3.1: Substitution / 3.2: Elimination / 4.1: Addition;

DOI:10.1002/ps.2780420402

Reference yield:

6-Chloro-2,4-diisopropyl-3-nitropyridine (133980-89-9) → 1-tert-butyl-3-[6-(2-fluoro-phenoxy)-2,4-diisopropyl-pyridin-3-yl]-thiourea (133979-35-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylsulfoxide

2.1: 91 percent / H₂ / Ra-Ni / ethanol; tetrahydrofuran / 30 - 35 °C

3.1: Et₃N / pyridine / -10 °C

3.2: DCC / pyridine / 20 °C

4.1: 86 percent / toluene / Heating

With hydrogen; potassium carbonate; triethylamine; Ra-Ni; In tetrahydrofuran; pyridine; ethanol; dimethyl sulfoxide; toluene; 1.1: condensation / 2.1: Reduction / 3.1: Substitution / 3.2: Elimination / 4.1: Addition;

DOI:10.1002/ps.2780420402

upstream raw materials:

tert-butylamine

6-(2-fluoro-phenoxy)-2,4-diisopropyl-3-isothiocyanato-pyridine

2-fluorophenol

6-Chloro-2,4-diisopropyl-3-nitropyridine

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