phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate

Base Information

• Chemical Name: phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate
• CAS No.: 116817-79-9
• Molecular Formula: C₂₅H₂₃NO₃S
• Molecular Weight: 417.529
• Mol file: 116817-79-9.mol

Synonyms:phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate

Chemical Property of phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate

There total 4 articles about phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl chloroformate (1885-14-9) + N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine (116817-11-9) → phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate (116817-79-9)

Guidance literature:

In toluene;

DOI:10.1016/j.bmcl.2003.08.079

Reference yield:

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol (13636-02-7,132335-44-5,132335-49-0) → phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate (116817-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH; DMA

2: toluene

With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride; In toluene;

DOI:10.1016/j.bmcl.2003.08.079

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate (116817-79-9)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. HCl / ethanol

2: aq. K₂CO₃; NaBH₄ / methanol

3: NaH; DMA

4: toluene

With hydrogenchloride; sodium tetrahydroborate; 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride; potassium carbonate; In methanol; ethanol; toluene; 1: Mannich reaction;

DOI:10.1016/j.bmcl.2003.08.079

upstream raw materials:

phenyl chloroformate

N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine

2-Acetylthiophene

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol

Downstream raw materials:

duloxetine