(RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride

Base Information

• Chemical Name: (RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride
• CAS No.: 116817-11-9
• Molecular Formula: C18H19ONS^.HCl
• Molecular Weight: 311.448
• Hs Code.: 2934999090
• Mol file: 116817-11-9.mol

Synonyms:N,N-Dimethyl-3-((1-naphthalenyl)oxy)-3-(2-thienyl)propanamine;N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine;N,N-Dimethyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine;

Chemical Property of (RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride

Chemical Property:

• Vapor Pressure: 7.23E-09mmHg at 25°C
• Melting Point: 118-122oC
• Boiling Point: 466.2 °C at 760 mmHg
• PKA: 9.19±0.28(Predicted)
• Flash Point: 235.7 °C
• PSA: 49.50000
• Density: 1.146±0.06 g/cm3(Predicted)
• LogP: 5.82380
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride

There total 10 articles about (RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine (878757-08-5) → N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine (116817-11-9)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 110 ℃; for 2h; Product distribution / selectivity;

Reference yield: 82.8%

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol (13636-02-7,132335-44-5,132335-49-0) + 1-Fluoronaphthalene (321-38-0) → N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine (116817-11-9)

Guidance literature:

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol; With potassium hydroxide; at 20 ℃; for 0.5h;

1-Fluoronaphthalene; In water; dimethyl sulfoxide; at 90 ℃; for 12h;

Reference yield:

2-(naphthalen-1-yloxymethyl)-thiophene + 2-(dimethylamino)ethyl chloride (107-99-3) → N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine (116817-11-9)

Guidance literature:

2-(naphthalen-1-yloxymethyl)-thiophene; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.5h;

2-(dimethylamino)ethyl chloride; In tetrahydrofuran; at -50 - 20 ℃; for 14h;

upstream raw materials:

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol

1-Fluoronaphthalene

N,N-dimethyl-3-(1-naphthalenyloxy)-3-(thien-2-yl)propanamine oxalate

2-Acetylthiophene

Downstream raw materials:

N-[4-(3-trifluoromethylphenylpiperazinyl)propyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

N-[4-(4-(2-methoxyphenylpiperazinyl))butyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

N-[4-(4-(3-trifluoromethylphenylpiperazinyl))butyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

N-[4-(2-methoxyphenylpiperazinyl)acetyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF N-METHYL-O-ARYLOXY PROPANAMINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF". Paragraph 0071-0074. . Retrieved 2013/03/26.
• 2、 -. "NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE". Page/Page column 20. . Retrieved 2008/12/07.