(2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

Base Information

Chemical Name:(2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine
CAS No.:459810-21-0
Molecular Formula:C₆₂H₆₄O₁₂
Molecular Weight:1001.18
Hs Code.:

(2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

Synonyms:(2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

Suppliers and Price of (2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

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Chemical Property of (2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

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Technology Process of (2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

There total 8 articles about (2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 132201-75-3
2,3,4,6-tetra-O-benzyl-D-glucopyranose trichloroacetimidate

: 459810-20-9
(2R,4aR,6S,7S,8S,8aS)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-ol

: 459810-21-0
(2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,4-dioxane; at 20 ℃; for 0.5h;
DOI:10.1016/S0960-894X(02)00151-8

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 459810-21-0
(2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / HBF₄ / diethyl ether; dimethylformamide / 24 h

2: 55 percent / aq. NaOH; Bu₄NHSO₄ / CH₂Cl₂

3: 71 percent / TMSOTf / dioxane / 0.5 h / 20 °C

With sodium hydroxide; tetrafluoroboric acid; trimethylsilyl trifluoromethanesulfonate; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00151-8

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 459810-21-0
(2R,4aR,6S,7S,8S,8aR)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-2-phenyl-8-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / CF₃SO₃Ag; sym-collidine; molecular sieves 4A / CH₂Cl₂ / 15 h / 20 °C

2: NaOMe / methanol / 24 h / 20 °C

3: 42 percent / HBF₄ / diethyl ether; dimethylformamide / 24 h

4: 55 percent / aq. NaOH; Bu₄NHSO₄ / CH₂Cl₂

5: 71 percent / TMSOTf / dioxane / 0.5 h / 20 °C

With 2,4,6-trimethyl-pyridine; sodium hydroxide; tetrafluoroboric acid; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sodium methylate; silver trifluoromethanesulfonate; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00151-8