(R)-3-Amino-3-(2-chloro-phenyl)-propionic acid

Base Information

• Chemical Name: (R)-3-Amino-3-(2-chloro-phenyl)-propionic acid
• CAS No.: 740794-79-0
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.637
• Mol file: 740794-79-0.mol

Synonyms:(R)-3-Amino-3-(2-chlorophenyl)propanoicacid

Chemical Property of (R)-3-Amino-3-(2-chloro-phenyl)-propionic acid

Chemical Property:

• Melting Point: 235-239 °C (sublm)(Solv: water (7732-18-5); acetone (67-64-1))
• Boiling Point: 336.5±32.0 °C(Predicted)
• PKA: 3.62±0.10(Predicted)
• PSA: 63.32000
• Density: 1.333±0.06 g/cm3(Predicted)
• LogP: 2.51480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Benzenepropanoicacid,?-amino-2-chloro-,(?R)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-Amino-3-(2-chloro-phenyl)-propionic acid

There total 13 articles about (R)-3-Amino-3-(2-chloro-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

malonic acid (141-82-2) + 2-chloro-benzaldehyde (89-98-5) → 3-amino-3-(2-chloro-phenyl)-propionic acid (68208-20-8,740794-79-0)

Guidance literature:

With ammonium acetate; In ethanol; for 6h; Reflux;

DOI:10.1080/10826068.2012.719847

Reference yield: 64.0%

malonic acid (141-82-2) + 2-chloro-benzaldehyde (89-98-5) → trans-2-chlorocinnamic acid (704-96-1,939-58-2) + 3-amino-3-(2-chloro-phenyl)-propionic acid (68208-20-8,740794-79-0)

Guidance literature:

With ammonium acetate; In butan-1-ol; Heating;

DOI:10.1007/s11176-005-0377-9

Reference yield: 48.0%

(+/-)-4-(2-chlorophenyl)-2-azetidinone (83716-63-6) → (S)-4-(2-chlorophenyl)-2-azetidinone (930769-47-4) + (R)-3-amino-3-(2-chlorophenyl)propionic acid (740794-79-0)

Guidance literature:

With CAL-B (lipase B from Candida antarctica); water; In isopropyl alcohol; at 60 ℃; for 14h;

DOI:10.1002/adsc.200505434

upstream raw materials:

ethanol

malonic acid

ammonium acetate

2-chloro-benzaldehyde

Downstream raw materials:

C₁₁H₁₄O₂NCl*HCl