5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate)

Base Information

• Chemical Name: 5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate)
• CAS No.: 91592-77-7
• Molecular Formula: C₄₃H₃₉ClN₅O₁₀P
• Molecular Weight: 852.237
• Mol file: 91592-77-7.mol

Synonyms:5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate)

Chemical Property of 5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate)

There total 2 articles about 5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzotriazol-1-ol (2592-95-2) → 5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate) (91592-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1,4-dioxane / 2 h

2: pyridine / 1,4-dioxane

With pyridine; In 1,4-dioxane;

DOI:10.1002/ejoc.201301352

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → 5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate) (91592-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentoxide; pyridine / 1,4-dioxane / 2 h

2: pyridine / 1,4-dioxane / 3 h / 20 °C

With pyridine; phosphorus pentoxide; In 1,4-dioxane;

DOI:10.3762/bjoc.11.171

Reference yield: 74.0%

5’-O-(4,4’-dimethoxytrityl)thymidine 3’-(benzotrizol-1-yl 2-chlorophenyl phosphate) (91592-77-7) + N6-benzoyl-2'-deoxyadenosine (4546-72-9) → C54H51ClN7O13P (84757-86-8)

Guidance literature:

In 1,4-dioxane; pyridine; at 20 ℃; for 1h;

DOI:10.1016/0040-4020(84)85104-2

upstream raw materials:

benzotriazol-1-ol

2-chlorophenyl dichlorophosphate

Downstream raw materials:

C₆₁H₅₇ClN₇O₁₄P

C₅₃H₅₁ClN₅O₁₄P

C₅₄H₅₁ClN₇O₁₃P

5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine