1H-3-Benzazepine, 3-acetyl-2,3,4,5-tetrahydro-

Base Information

Chemical Name:1H-3-Benzazepine, 3-acetyl-2,3,4,5-tetrahydro-
CAS No.:10533-22-9
Molecular Formula:C12H15NO
Molecular Weight:189.257
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-3-Benzazepine, 3-acetyl-2,3,4,5-tetrahydro-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-3-Benzazepine, 3-acetyl-2,3,4,5-tetrahydro-

There total 1 articles about 1H-3-Benzazepine, 3-acetyl-2,3,4,5-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 848772-61-2
N-[2-(2-bromophenyl)ethyl]-N-ethenylacetamide

: N-ethenyl-N-(2-phenylethyl)acetamide

: 10533-22-9
1-(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethanone

Guidance literature:: With tri-n-butyl-tin hydride; 1,1'-azobis(1-cyanocyclohexanenitrile); In toluene; for 1h; Heating;
DOI:10.1021/jo040264u

Reference yield:

: 10533-22-9
1-(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethanone

: 264264-45-1
trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / CH₂Cl₂ / 18 h / 20 °C

2.1: sodium sulfite; aq. sodium hydrogen carbonate / tetrahydrofuran / 2 h / 75 °C

2.2: tetrahydrofuran; H₂O / 24 h / 50 °C

3.1: aq. HCl / 18 h / Heating

4.1: 90 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 48 h / 20 °C

5.1: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; chlorosulfonic acid; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; trifluoroacetic acid; sodium sulfite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030817d

Reference yield:

: 10533-22-9
1-(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethanone

: 264264-44-0
trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / CH₂Cl₂ / 18 h / 20 °C

2.1: sodium sulfite; aq. sodium hydrogen carbonate / tetrahydrofuran / 2 h / 75 °C

2.2: tetrahydrofuran; H₂O / 24 h / 50 °C

3.1: aq. HCl / 18 h / Heating

4.1: 90 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 48 h / 20 °C

With hydrogenchloride; chlorosulfonic acid; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; sodium sulfite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030817d