Technology Process of 3-benzyloxy-2-nitrophenyl-acetic acid
There total 7 articles about 3-benzyloxy-2-nitrophenyl-acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(benzyloxy)-3-methyl-2-nitrobenzene;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.5h;
Inert atmosphere;
oxalic acid diethyl ester;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 50 ℃;
Further stages;
Inert atmosphere;
DOI:10.1021/ol902566p
- Guidance literature:
-
(3-benzyloxy-2-nitro-phenyl)-pyruvic acid;
With
dihydrogen peroxide; sodium hydroxide;
In
1,4-dioxane;
at 20 ℃;
for 1h;
Inert atmosphere;
With
hydrogenchloride;
In
1,4-dioxane; water;
pH=3;
DOI:10.1271/bbb.100124
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 2.5 h / 75 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl methyl ether / 24 h / Inert atmosphere; Heating
3.1: sodium hydroxide / ethanol; water / 2.5 h / 20 °C / Inert atmosphere
3.2: pH 3
4.1: dihydrogen peroxide; sodium hydroxide / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
4.2: pH 3
With
potassium tert-butylate; dihydrogen peroxide; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; tert-butyl methyl ether; water; acetonitrile;
DOI:10.1271/bbb.100124
