methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate

Base Information

Chemical Name:methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate
CAS No.:1638677-54-9
Molecular Formula:C₃₁H₃₅NO₅
Molecular Weight:501.623
Hs Code.:

Synonyms:methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate

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Chemical Property of methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate

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Technology Process of methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate

There total 5 articles about methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1638677-39-0
(S)-4-(2-(N-benzylpivalamido)-3-methoxy-3-oxopropyl)phenyl pivalate

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1638677-54-9
methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); In toluene; at 150 ℃; for 24h; Inert atmosphere; Glovebox;
DOI:10.1002/anie.201403823

Reference yield: 79.0%

: 1638677-54-9
methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); In toluene; at 150 ℃; for 24h; Inert atmosphere; Glovebox;

Reference yield:

: 100-52-7
benzaldehyde

: 1638677-54-9
methyl (S)-2-(N-benzylpivalamido)-3-(4-(2-(4-methoxyphenyl)-2-oxoethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3: 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate / toluene / 24 h / 150 °C / Inert atmosphere; Glovebox

With dmap; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/anie.201403823