{[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester

Base Information

Chemical Name:{[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester
CAS No.:1259276-32-8
Molecular Formula:C₁₃H₁₈N₂O₅
Molecular Weight:282.296
Hs Code.:

Synonyms:{[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester

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Chemical Property of {[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester

Chemical Property:

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Technology Process of {[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester

There total 2 articles about {[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13515-93-0
N-methylglycine methyl ester hydrochloride

: 30033-24-0
(2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoic acid

: 1259276-32-8
{[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester

Guidance literature:: N-methylglycine methyl ester hydrochloride; (2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.07.017

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 1259276-32-8
{[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; sodium hydrogencarbonate / dichloromethane / 0 - 20 °C

3: hydrogenchloride / diethyl ether / 1 h / 0 °C

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In 1,4-dioxane; diethyl ether; dichloromethane; water;

Reference yield:

: 1259276-32-8
{[2-(S)-amino-3-(3,4-dihydroxy-phenyl)-propionyl]-methyl-amino}-acetic acid methyl ester

: (2S,8S)-2-(1-benzyl-1H-indol-3-yl)-6-methyl-13,15-dioxa-3,6-diazatetracyclo-[8.7.0.0(3,8)0.0(12,16)]heptadeca-1⁽¹⁰⁾,11,16-triene-4,7-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; acetic acid / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 150 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 4 h / 20 °C

With sodium acetate; sodium hydride; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;