tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester

Base Information

Chemical Name:tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester
CAS No.:870838-58-7
Molecular Formula:C₁₈H₂₀N₂O₃
Molecular Weight:312.368
Hs Code.:

Synonyms:tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester

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Chemical Property of tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester

Chemical Property:

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Technology Process of tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester

There total 6 articles about tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870838-57-6
1-(4-iodine-2-methoxyphenyl)-4-methyl-1H-imidazole

: 13831-03-3
tert-butyl prop-2-ynoate

: 870838-58-7
tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester

Guidance literature:: With copper(l) iodide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h;

Reference yield:

: 870838-56-5
1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

: 870838-58-7
tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 9 h / 110 °C

2: copper(l) iodide; potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 100 °C

With copper(l) iodide; potassium carbonate; sodium iodide; N,N`-dimethylethylenediamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 870838-52-1
o-bromotrifluoroacetanilide

: 870838-58-7
tert-butyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propiolic acid ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 0.5 h

2.1: formic acid / 0.5 h / 0 °C

2.2: 0.5 h

3.1: ammonium acetate; acetic acid / 0.5 h / 120 °C

4.1: copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 9 h / 110 °C

5.1: copper(l) iodide; potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 100 °C

With copper(l) iodide; formic acid; ammonium acetate; potassium carbonate; caesium carbonate; acetic acid; potassium iodide; sodium iodide; N,N`-dimethylethylenediamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; N,N-dimethyl-formamide;