(2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate
• CAS No.: 1552271-81-4
• Molecular Formula: C₃₄H₃₅NO₃
• Molecular Weight: 505.657

Synonyms:(2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate

Chemical Property of (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate

There total 3 articles about (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2S,5S)-1-tert-butyl 2-methyl-5-([1,1’-biphenyl]-4-yl)pyrrolidine-1,2-dicarboxylate (1552271-26-7) + phenylmagnesium bromide (100-58-3) → (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate (1552271-81-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ja4129394

Reference yield:

4-biphenylylmagnesium bromide (3315-91-1) → (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate (1552271-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; diethyl ether / 1 h / -40 °C / Inert atmosphere

1.2: 16 h / -78 - 4 °C / Inert atmosphere

2.1: tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja4129394

Reference yield:

1-tert-butyl 2-methyl (2S)-5-methoxypyrrolidine-1,2-dicarboxylate (195964-54-6) → (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate (1552271-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; diethyl ether / 1 h / -40 °C / Inert atmosphere

1.2: 16 h / -78 - 4 °C / Inert atmosphere

2.1: tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja4129394

upstream raw materials:

(2S,5S)-1-tert-butyl 2-methyl-5-([1,1’-biphenyl]-4-yl)pyrrolidine-1,2-dicarboxylate

phenylmagnesium bromide

1-tert-butyl 2-methyl (2S)-5-methoxypyrrolidine-1,2-dicarboxylate

4-biphenylylmagnesium bromide

Downstream raw materials:

((2S,2'S,5S,5'S)-1,1'-((2-hydroxy-5-methyl-1,3-phenylene)-bis-(methylene))-bis-(5-([1,1'-biphenyl]-4-yl)pyrrolidine-2,1-diyl))-bis-(diphenylmethanol)

[(2S,5S)-5-([1,1'-biphenyl]-4-yl)pyrrolidin-2-yl]diphenylmethanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1552271-81-4 (2S,5S)-tert-butyl 2-([1,1'-biphenyl]-4-yl)-5-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send