ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate

Base Information

• Chemical Name: ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate
• CAS No.: 1407969-00-9
• Molecular Formula: C₇₁H₈₈N₂O₁₁
• Molecular Weight: 1145.49
• Mol file: 1407969-00-9.mol

Synonyms:ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate

Chemical Property of ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate

There total 4 articles about ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C39H54O5 (1407968-99-3) + 3-(benzyloxy)-1-(2-(2-iodoethoxy)ethyl)pyridin-2(1H)-one (238420-42-3) → ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate (1407969-00-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tet.2012.09.032

Reference yield:

4-(tert-butyl)-2,6-bis{[5-(tert-butyl)-2-hydroxyphenyl]methyl}phenol (810-52-6) → ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate (1407969-00-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 - 70 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2012.09.032

Reference yield:

2,6-bis(5-tert-butyl-2-(tert-butyldiphenylsilyloxy)benzyl)-4-tert-butylphenol (1407968-95-9) → ethyl 5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)pentanoate (1407969-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 - 70 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2012.09.032

upstream raw materials:

2,6-bis(5-tert-butyl-2-(tert-butyldiphenylsilyloxy)benzyl)-4-tert-butylphenol

ethyl 5-(2,6-bis(5-tert-butyl-2-(tert-butyldiphenylsilyloxy)benzyl)-4-tert-butylphenoxy)pentanoate

C₃₉H₅₄O₅

3-(benzyloxy)-1-(2-(2-iodoethoxy)ethyl)pyridin-2(1H)-one

Downstream raw materials:

5-(2,6-bis(2-(2-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)-5-tertbutylbenzyl)-4-tert-butylphenoxy)-N-(benzyloxy)pentanamide

5-(2,6-bis(5-tert-butyl-2-(2-(2-(3-hydroxy-2-oxopyridin-1(2H)-yl)ethoxy)ethoxy)benzyl)-4-tert-butylphenoxy)-N-hydroxypentanamide