tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate
CAS No.:1315464-84-6
Molecular Formula:C₁₉H₂₅BrF₃NO₃
Molecular Weight:452.312
Hs Code.:

Synonyms:tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50824-04-9
4-bromo-2-(trifluoromethyl)phenol

: 89151-44-0
4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

: 1315464-84-6
tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 20.25h;

Reference yield:

: 1315464-84-6
tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate

: 73183-34-3
bis(pinacol)diborane

: 1315464-85-7
tert-butyl 4-{2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenoxy]ethyl}piperidine-1-carboxylate

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1315464-84-6
tert-butyl 4-(2-[4-bromo-2-(trifluoromethyl)phenoxy]ethyl)piperidine-1-carboxylate

: 1315462-65-7
1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

3: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 1.03 h / 5 - 20 °C

4: dichloromethane; acetonitrile / 0.17 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 100 °C / Microwaves

With hydrogenchloride; potassium acetate; N-ethyl-N,N-diisopropylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; dimethyl sulfoxide; acetonitrile;