2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Base Information

• Chemical Name: 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole
• CAS No.: 1307884-77-0
• Molecular Formula: C₁₆H₁₂Cl₃N₃O
• Molecular Weight: 368.65
• Mol file: 1307884-77-0.mol

Synonyms:2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Chemical Property of 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

There total 4 articles about 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(4-aminophenyl)-5,6-dichloro-1-methyl-1H-benzimidazole (1307884-76-9) + chloroacetyl chloride (79-04-9) → 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole (1307884-77-0)

Guidance literature:

With triethylamine; In benzene; at 20 ℃; for 1h; Cooling with ice;

DOI:10.1002/ardp.201000172

Reference yield:

2-(4-acetylaminophenyl)-5,6-dichloro-1H-benzimidazole (1224878-33-4) → 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole (1307884-77-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 12 h / Reflux

2: hydrogenchloride / water / 1 h / Reflux

3: triethylamine / benzene / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; potassium carbonate; triethylamine; In water; acetone; benzene;

DOI:10.1002/ardp.201000172

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) → 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole (1307884-77-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium metabisulfite / ethanol / 0.5 h / 20 °C

1.2: 4 h / 130 °C

2.1: potassium carbonate / acetone / 12 h / Reflux

3.1: hydrogenchloride / water / 1 h / Reflux

4.1: triethylamine / benzene / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium metabisulfite; potassium carbonate; triethylamine; In ethanol; water; acetone; benzene;

DOI:10.1002/ardp.201000172

upstream raw materials:

4,5-Dichloro-1,2-phenylenediamine

2-(4-acetylaminophenyl)-5,6-dichloro-1H-benzimidazole

2-(4-aminophenyl)-5,6-dichloro-1-methyl-1H-benzimidazole

chloroacetyl chloride

Downstream raw materials:

5,6-dichloro-1-methyl-2-[4-[2-[(4H-1,2,4-triazole-3-yl)sulfanyl]acetylamino]phenyl]-1H-benzimidazole

5,6-dichloro-1-methyl-2-[4-[2-[(5-methyl-1,2,4-thiadiazole-3-yl)sulfanyl]acetylamino]phenyl]-1H-benzimidazole

5,6-dichloro-1-methyl-2-[4-[2-[(4-methyl-4H-1,2,4-triazole-3-yl)sulfanyl]acetylamino]phenyl]-1H-benzimidazole

5,6-dichloro-1-methyl-2-[4-[2-[(1-methy-1H-1,2,3,4-tetrazole-5-yl)sulfanyl]acetylamino]phenyl]-1H-benzimidazole