2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Base Information

Chemical Name:2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole
CAS No.:1307884-77-0
Molecular Formula:C₁₆H₁₂Cl₃N₃O
Molecular Weight:368.65
Hs Code.:

Synonyms:2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

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Chemical Property of 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Chemical Property:

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Technology Process of 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

There total 4 articles about 2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1307884-76-9
2-(4-aminophenyl)-5,6-dichloro-1-methyl-1H-benzimidazole

: 79-04-9
chloroacetyl chloride

: 1307884-77-0
2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Guidance literature:: With triethylamine; In benzene; at 20 ℃; for 1h; Cooling with ice;
DOI:10.1002/ardp.201000172

Reference yield:

: 1224878-33-4
2-(4-acetylaminophenyl)-5,6-dichloro-1H-benzimidazole

: 1307884-77-0
2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 12 h / Reflux

2: hydrogenchloride / water / 1 h / Reflux

3: triethylamine / benzene / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; potassium carbonate; triethylamine; In water; acetone; benzene;
DOI:10.1002/ardp.201000172

Reference yield:

: 5348-42-5
4,5-Dichloro-1,2-phenylenediamine

: 1307884-77-0
2-[4-(2-chloroacetylamino)phenyl]-5,6-dichloro-1-methyl-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium metabisulfite / ethanol / 0.5 h / 20 °C

1.2: 4 h / 130 °C

2.1: potassium carbonate / acetone / 12 h / Reflux

3.1: hydrogenchloride / water / 1 h / Reflux

4.1: triethylamine / benzene / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium metabisulfite; potassium carbonate; triethylamine; In ethanol; water; acetone; benzene;
DOI:10.1002/ardp.201000172