methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

Base Information

Chemical Name:methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
CAS No.:191542-15-1
Molecular Formula:C₁₄H₁₇Cl₂NO₅
Molecular Weight:350.199
Hs Code.:

Synonyms:methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

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Technology Process of methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

There total 4 articles about methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 191542-14-0
methyl (2R)-2-amino-2-(3,5-dichloro-4-hydroxyphenyl)acetate

: 191542-15-1
methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; for 6h; Ambient temperature;
DOI:10.1055/s-1997-1234

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 37763-23-8
D-2-p-hydroxyphenylglycine methyl ester

: methyl (2R)-2-(3-chloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

: 191542-15-1
methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

Guidance literature:: D-2-p-hydroxyphenylglycine methyl ester; With sulfuryl dichloride; In acetic acid; at 25 ℃; for 16h;

With sodium hydroxide; In water; pH=14;

di-tert-butyl dicarbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 16h;
DOI:10.1021/acs.jmedchem.1c00034

Reference yield:

: p-hydroxyphenylglycine hydrochloride

: 191542-15-1
methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / HCl (g), SO₂Cl₂ / acetic acid / a) 70 deg C, 30 min, b) RT, 2 h

2: 93 percent / SOCl₂ / 72 h / Ambient temperature

3: 68 percent / NaHCO₃ / H₂O; tetrahydrofuran / 6 h / Ambient temperature

With hydrogenchloride; thionyl chloride; sulfuryl dichloride; sodium hydrogencarbonate; In tetrahydrofuran; water; acetic acid;
DOI:10.1055/s-1997-1234