2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

Base Information

• Chemical Name: 2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide
• CAS No.: 1620657-87-5
• Molecular Formula: C₂₆H₂₅N₂O₂P
• Molecular Weight: 428.47
• Mol file: 1620657-87-5.mol

Synonyms:2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

Chemical Property of 2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

There total 5 articles about 2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(aminomethyl)-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1439568-51-0) + benzaldehyde (100-52-7) → 2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1620657-87-5)

Guidance literature:

2-(aminomethyl)-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide; benzaldehyde; In methanol; at 23 ℃; for 18h; Inert atmosphere; Schlenk technique;

With sodium tetrahydroborate; In methanol; at 23 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.201400120

Reference yield:

2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione (628308-52-1) → 2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1620657-87-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 16 h / 120 °C / Inert atmosphere; Schlenk technique

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

3.1: hydrazine hydrate / methanol / 16 h / 90 °C / Inert atmosphere; Schlenk technique

4.1: methanol / 18 h / 23 °C / Inert atmosphere; Schlenk technique

4.2: 4 h / 23 °C / Inert atmosphere; Schlenk technique

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1002/ejoc.201400120

Reference yield:

2-({6-[(diphenylphosphoryl)methyl]pyridin-2-yl}methyl)isoindoline-1,3-dione (1620657-78-4) → 2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1620657-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

2.1: hydrazine hydrate / methanol / 16 h / 90 °C / Inert atmosphere; Schlenk technique

3.1: methanol / 18 h / 23 °C / Inert atmosphere; Schlenk technique

3.2: 4 h / 23 °C / Inert atmosphere; Schlenk technique

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1002/ejoc.201400120

upstream raw materials:

2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione

2-({6-[(diphenylphosphoryl)methyl]pyridin-2-yl}methyl)isoindoline-1,3-dione

2,6-bis(chloromethyl)pyridine

2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide