3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one

Base Information

Chemical Name:3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one
CAS No.:924300-40-3
Molecular Formula:C₂₉H₄₁NO₅Si
Molecular Weight:511.734
Hs Code.:

Synonyms:3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one

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Chemical Property of 3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one

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Technology Process of 3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one

There total 6 articles about 3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 884502-04-9
2,4-dimethoxy-N,6-dimethylbenzamide

: 924300-39-0
4-[2-(tert-butyldimethylsilanyloxy)-2-methylpropoxy]-3,5-dimethylbenzonitrile

: 924300-40-3
3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one

Guidance literature:: 2,4-dimethoxy-N,6-dimethylbenzamide; With n-butyllithium; In tetrahydrofuran; hexane; at -10 - 0 ℃; for 1.16667h;

4-[2-(tert-butyldimethylsilanyloxy)-2-methylpropoxy]-3,5-dimethylbenzonitrile; In tetrahydrofuran; hexane; at -50 - 20 ℃; for 1h;

Reference yield: 37.0%

: 924300-39-0
4-[2-(tert-butyldimethylsilanyloxy)-2-methylpropoxy]-3,5-dimethylbenzonitrile

: 924300-40-3
3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one

Guidance literature:: N,N-dimethyl-2,4-dimethoxybenzamide; With n-butyllithium; In tetrahydrofuran; hexane; at -10 - 0 ℃; for 1.16667h;

4-[2-(tert-butyldimethylsilanyloxy)-2-methylpropoxy]-3,5-dimethylbenzonitrile; In tetrahydrofuran; hexane; at -50 - 20 ℃; for 1h;

Reference yield:

: 3686-57-5
2,4-dimethoxy-6-methylbenzoic acid

: 924300-40-3
3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane / 16 h / 20 °C

1.2: 4 h / 20 °C / Cooling

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.17 h / -10 - 0 °C / Inert atmosphere

2.2: 1 h / -50 - 20 °C

With n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane; dichloromethane;