5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine
CAS No.:771493-96-0
Molecular Formula:C₃₆H₄₃N₅O₆Si
Molecular Weight:669.853
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 771493-90-4
5'-O-(4,4'-dimethoxytrityl)-8-azanebularine

: 771493-96-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine

Guidance literature:: With TEA; silver nitrate; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1021/ja0472073

Reference yield:

: 38874-46-3
8-azanebularine ribonucleoside

: 771493-96-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / pyridine; AgNO₃ / tetrahydrofuran / 20 °C

2: 42 percent / TEA; AgNO₃ / tetrahydrofuran / 8 h / 20 °C

With pyridine; TEA; silver nitrate; In tetrahydrofuran;
DOI:10.1021/ja0472073

Reference yield:

: 92516-90-0
2',3',5'-tri-O-acetyl-8-azaadenosine

: 771493-96-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-8-azanebularine

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / tBuONO; TMSBr / acetonitrile / 1 h / 0 °C

2: 80 percent / H₂; NaOAc / methanol / 8 h / 1900 Torr

3: 81 percent / methanolic NH₃ / 4 °C

4: 65 percent / pyridine; AgNO₃ / tetrahydrofuran / 20 °C

5: 42 percent / TEA; AgNO₃ / tetrahydrofuran / 8 h / 20 °C

With pyridine; tert.-butylnitrite; trimethylsilyl bromide; TEA; ammonia; hydrogen; sodium acetate; silver nitrate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ja0472073