2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide

Base Information

• Chemical Name: 2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide
• CAS No.: 910110-24-6
• Molecular Formula: C₃₁H₃₁F₁₂NOSSi
• Molecular Weight: 721.726

Synonyms:2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide

Chemical Property of 2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide

Chemical Property:

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MSDS Files:

Useful:

Technology Process of 2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide

There total 1 articles about 2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-(hexafluoroisopropylidene)aniline (2002-95-1) + [1-(2-Benzylsulfanyl-phenyl)-2,2,2-trifluoro-1-trifluoromethyl-ethoxy]-tert-butyl-dimethyl-silane (185030-87-9) → 2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide (910110-24-6)

Guidance literature:

[1-(2-Benzylsulfanyl-phenyl)-2,2,2-trifluoro-1-trifluoromethyl-ethoxy]-tert-butyl-dimethyl-silane; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

N-(hexafluoroisopropylidene)aniline; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1021/ol0618499

Reference yield:

2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide (910110-24-6) → benzaldehyde (100-52-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / n-Bu₄NF / tetrahydrofuran / 0.5 h / 0 °C

2: 15 percent / mCPBA / CHCl₃ / 0.08 h / 20 °C

3: 15 percent / RuO₄ / CCl₄ / 5 h / -10 °C

4: 6 percent Spectr_. / toluene-d8 / 17 h / 160 °C

With ruthenium tetroxide; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; chloroform; ⁽²⁾H₈-toluene;

DOI:10.1021/ol0618499

Reference yield:

2-[1-t-butyldimethylsiloxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl 3,3,3-trifluoro-1-phenyl-2-phenylamino-2-(trifluoromethyl)propyl sulfide (910110-24-6) → N-(1,1,1,3,3,3-hexafluoropropyl)aniline (1736-12-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / n-Bu₄NF / tetrahydrofuran / 0.5 h / 0 °C

2: 15 percent / mCPBA / CHCl₃ / 0.08 h / 20 °C

3: 15 percent / RuO₄ / CCl₄ / 5 h / -10 °C

4: 6 percent Spectr_. / toluene-d8 / 17 h / 160 °C

With ruthenium tetroxide; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; chloroform; ⁽²⁾H₈-toluene;

DOI:10.1021/ol0618499

upstream raw materials:

N-(hexafluoroisopropylidene)aniline

[1-(2-Benzylsulfanyl-phenyl)-2,2,2-trifluoro-1-trifluoromethyl-ethoxy]-tert-butyl-dimethyl-silane

Downstream raw materials:

trans-2',4'-diphenyl-3,3,3',3'-tetrakis(trifluoromethyl)-3H-spiro[[2,1]benzoxathiole-1λ⁶,1'-[1,2]thiazetidine] 1-oxide

N-(1,1,1,3,3,3-hexafluoropropyl)aniline

benzaldehyde

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