1-[4-[(2-Chlorophenyl)methyl]phenyl]ethanone

Base Information

• Chemical Name: 1-[4-[(2-Chlorophenyl)methyl]phenyl]ethanone
• CAS No.: 33781-48-5
• Molecular Formula: C₁₅H₁₃ClO
• Molecular Weight: 244.721
• DSSTox Substance ID: DTXSID001258880
• Mol file: 33781-48-5.mol

Synonyms:1-[4-[(2-chlorophenyl)methyl]phenyl]ethanone;DTXSID001258880;33781-48-5

Chemical Property of 1-[4-[(2-Chlorophenyl)methyl]phenyl]ethanone

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 244.0654927
• Heavy Atom Count: 17
• Complexity: 256

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)CC2=CC=CC=C2Cl

Technology Process of 1-[4-[(2-Chlorophenyl)methyl]phenyl]ethanone

There total 1 articles about 1-[4-[(2-Chlorophenyl)methyl]phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(o-benzyl)chlorobenzene (29921-41-3) + acetyl chloride (75-36-5) → 2-Chlor-4'-acetyldiphenylmethan (33781-48-5)

Guidance literature:

With aluminium trichloride;

DOI:10.1021/ja00746a018

Reference yield: 65.0%

1,2,3,6-tetrahydro-4-phenylpyridine (10338-69-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Chlor-4'-acetyldiphenylmethan (33781-48-5) → 1-[4-(2-Chloro-benzyl)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-propan-1-one; hydrochloride

Guidance literature:

With hydrogenchloride; In ethanol; for 24h; Heating;

DOI:10.1016/0223-5234(94)90059-0

Reference yield:

2-Chlor-4'-acetyldiphenylmethan (33781-48-5) → 3-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-1-[4-(2-chloro-benzyl)-phenyl]-1-propanol

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / HCl / ethanol / 24 h / Heating

2: 82 percent / NaOH, NaBH₄ / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; In methanol; ethanol;

DOI:10.1016/0223-5234(94)90059-0

upstream raw materials:

(o-benzyl)chlorobenzene

acetyl chloride