4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide

Base Information

Chemical Name:4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide
CAS No.:1093403-43-0
Molecular Formula:C₂₄H₁₈N₈OS₂
Molecular Weight:498.592
Hs Code.:

Synonyms:4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide

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Chemical Property of 4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide

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Technology Process of 4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide

There total 8 articles about 4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1093403-45-2
2-(3-[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenylamine

: 39091-01-5
4-methyl-2-(pyridin-3-yl)-5-thiazolecarboxylic acid

: 1093403-43-0
4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 925437-84-9
6-(2-nitrophenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester

: 1093403-43-0
4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 3 h / 0 °C

2.2: 0.75 h / 0 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 30 °C

4.1: potassium carbonate / sodium iodide / N,N-dimethyl-formamide / 20 - 35 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; isobutyl chloroformate; palladium 10% on activated carbon; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6851-99-6
2-bromo-1-(2-nitrophenyl)ethanone

: 1093403-43-0
4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: butanone / 18 h / Heating / reflux

2.1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 3 h / 0 °C

3.2: 0.75 h / 0 °C

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 30 °C

5.1: potassium carbonate / sodium iodide / N,N-dimethyl-formamide / 20 - 35 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; isobutyl chloroformate; palladium 10% on activated carbon; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; butanone;