1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

Base Information

Chemical Name:1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil
CAS No.:131194-29-1
Molecular Formula:C₂₁H₃₀N₂O₄SSi
Molecular Weight:434.632
Hs Code.:

Synonyms:1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

Suppliers and Price of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

There total 4 articles about 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-<(2-acetoxyethoxy)methyl>-5-vinyluracil

: 131194-29-1
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) aq. ammonia, 2.) imidazole / 1.) MeOH, RT, 14 h, 2.) DMF, RT, 14 h

2: 1.) LDA / 1.) THF, -70 deg c, 1 h, 2.) -70 deg C, 1 h

With 1H-imidazole; ammonium hydroxide; lithium diisopropyl amide;
DOI:10.1021/jm00105a055

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 131194-29-1
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) aq. ammonia, 2.) imidazole / 1.) MeOH, RT, 14 h, 2.) DMF, RT, 14 h

2: 1.) LDA / 1.) THF, -70 deg c, 1 h, 2.) -70 deg C, 1 h

With 1H-imidazole; ammonium hydroxide; lithium diisopropyl amide;
DOI:10.1021/jm00105a055

Reference yield:

: 37107-81-6
5-vinyluracil

: 131194-29-1
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-vinyluracil

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) bis(trimethylsilyl)acetamide, 2.) tin(IV) chloride / 1.) CH₂Cl₂, RT, 2 h, 2.) RT, 14 h

2: 1.) aq. ammonia, 2.) imidazole / 1.) MeOH, RT, 14 h, 2.) DMF, RT, 14 h

3: 1.) LDA / 1.) THF, -70 deg c, 1 h, 2.) -70 deg C, 1 h

With 1H-imidazole; ammonium hydroxide; tin(IV) chloride; bis-(trimethylsilyl)acetamide; lithium diisopropyl amide;
DOI:10.1021/jm00105a055