2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Base Information

Chemical Name:2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile
CAS No.:1259926-30-1
Molecular Formula:C₃₃H₂₅F₃N₄O₃S
Molecular Weight:614.648
Hs Code.:

2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Synonyms:2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

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Chemical Property of 2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

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Technology Process of 2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

There total 9 articles about 2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

: 1259926-29-8
5-(2-{4-[(2-hydroxyethyl) methylamino]-2-methoxyphenyl}vinyl)thiophene-2-carbaldehyde

: 436097-14-2
[3-cyano-4-methyl-5-phenyl-5-(trifluoromethyl)-2(5H)-furanylidene]propanedinitrile

: 1259926-30-1
2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Guidance literature:: In tetrahydrofuran; ethanol; at 20 - 50 ℃; for 21h;

Reference yield:

: 14318-66-2
3-methoxy-N-methylaniline

: 1259926-30-1
2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydrogencarbonate / acetonitrile / 2 h / 90 °C

1.2: 16 h / 20 °C

2.1: sodium tetrahydroborate; lithium bromide / tetrahydrofuran / 21 h / 20 - 80 °C

3.1: pyridine / toluene / 3 h / 20 - 85 °C

4.1: trichlorophosphate / 0.67 h / Cooling with ice

4.2: 16 h

5.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.33 h / Cooling with ice

5.2: 2 h

6.1: sodium hydroxide; water / ethanol / 3 h / 20 - 45 °C

7.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

8.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

8.2: 1 h / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

10.1: ethanol; tetrahydrofuran / 21 h / 20 - 50 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; phenyllithium; lithium bromide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; dibutyl ether; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 33905-43-0
2-[(3-methoxyphenyl)-N-methylamino]ethanol

: 1259926-30-1
2-(3-cyano-4-{2-[5-(2-{4-[(2-hydroxyethyl)methylamino]-2-methoxyphenyl}vinyl)thiophene-2-yl]vinyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / toluene / 3 h / 20 - 85 °C

2.1: trichlorophosphate / 0.67 h / Cooling with ice

2.2: 16 h

3.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.33 h / Cooling with ice

3.2: 2 h

4.1: sodium hydroxide; water / ethanol / 3 h / 20 - 45 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.2: 1 h / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

8.1: ethanol; tetrahydrofuran / 21 h / 20 - 50 °C

With pyridine; 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; water; phenyllithium; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; dibutyl ether; N,N-dimethyl-formamide; toluene;