acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester

Base Information

Chemical Name:acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester
CAS No.:853247-16-2
Molecular Formula:C₂₀H₂₈O₅S₂
Molecular Weight:412.571
Hs Code.:

Synonyms:acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester

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Technology Process of acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester

There total 6 articles about acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 853247-15-1
6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

: 108-24-7
acetic anhydride

: 853247-16-2
acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo050414g

Reference yield:

: 705-76-0
3,5-dimethoxybenzyl alcohol

: 853247-16-2
acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 87 percent / POCl₃ / 60 °C

2.1: 95 percent / p-TsOH; molecular sieves 4 Angstroem / methanol / 50 °C

3.1: n-BuLi / tetrahydrofuran / -78 - -20 °C

3.2: 42 percent / tetrahydrofuran

4.1: 75 percent / n-BuLi / tetrahydrofuran / -78 - -10 °C

5.1: 92 percent / HCl / acetone / 4 h / 20 °C

6.1: 96 percent / triethylamine; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

With hydrogenchloride; dmap; n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo050414g

Reference yield:

: 166322-67-4
2-(chloromethyl)-4,6-dimethoxy-benzaldehyde

: 853247-16-2
acetic acid 3-[2-(2-formyl-3,5-dimethoxy-4-methylbenzyl)[1,3]dithian-2-yl]propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / p-TsOH; molecular sieves 4 Angstroem / methanol / 50 °C

2.1: n-BuLi / tetrahydrofuran / -78 - -20 °C

2.2: 42 percent / tetrahydrofuran

3.1: 75 percent / n-BuLi / tetrahydrofuran / -78 - -10 °C

4.1: 92 percent / HCl / acetone / 4 h / 20 °C

5.1: 96 percent / triethylamine; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

With hydrogenchloride; dmap; n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo050414g