3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Base Information

Chemical Name:3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one
CAS No.:123664-34-6
Molecular Formula:C₁₆H₁₄BrNO₅S
Molecular Weight:412.261
Hs Code.:

Synonyms:3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Suppliers and Price of 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

There total 9 articles about 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 123664-21-1
N-(4-oxo-6-phenoxy-2,3-dihydro-4H-7-chromenyl)methanesulfonamide

: 123664-34-6
3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Guidance literature:: With bromine; In chloroform; at 25 - 30 ℃; for 0.5h;
DOI:10.1248/cpb.48.131

Reference yield:

: 84594-95-6
5-methoxy-1-nitro-2-phenoxybenzene

: 123664-34-6
3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C

2: 82 percent / pyridine / 1 h / 20 °C

3: 84 percent / aluminum chloride / CH₂Cl₂ / 1 h / 15 - 20 °C

4: 70 percent aq. HClO₄ / 1 h / 20 °C

5: H₂O / 0.08 h / Heating

6: H₂ / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr

7: 97 percent / Br₂ / CHCl₃ / 0.5 h / 25 - 30 °C

With pyridine; hydrogenchloride; aluminium trichloride; perchloric acid; water; hydrogen; bromine; iron; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; acetic acid; 1: Reduction / 2: Mesylation / 3: Acetylation / 4: Cyclization / 5: Hydrolysis / 6: Catalytic hydrogenation / 7: Bromination;
DOI:10.1248/cpb.48.131

Reference yield:

: 76838-72-7
5-methoxy-2-phenoxyaniline

: 123664-34-6
3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / pyridine / 1 h / 20 °C

2: 84 percent / aluminum chloride / CH₂Cl₂ / 1 h / 15 - 20 °C

3: 70 percent aq. HClO₄ / 1 h / 20 °C

4: H₂O / 0.08 h / Heating

5: H₂ / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr

6: 97 percent / Br₂ / CHCl₃ / 0.5 h / 25 - 30 °C

With pyridine; aluminium trichloride; perchloric acid; water; hydrogen; bromine; palladium on activated charcoal; In dichloromethane; chloroform; acetic acid; 1: Mesylation / 2: Acetylation / 3: Cyclization / 4: Hydrolysis / 5: Catalytic hydrogenation / 6: Bromination;
DOI:10.1248/cpb.48.131