(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

Base Information

Chemical Name:(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
CAS No.:1560678-63-8
Molecular Formula:C₂₅H₂₇N₃O₅*ClH
Molecular Weight:485.967
Hs Code.:

Synonyms:(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

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Chemical Property of (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

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Technology Process of (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

There total 7 articles about (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1560678-59-2
(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione besylate benzenesulfonic acid

: 1560678-63-8
(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

Guidance literature:: With hydrogenchloride; sodium hydrogencarbonate; In acetic acid methyl ester; water; at 15 - 25 ℃; Inert atmosphere;

Reference yield:

: 1560678-56-9
tert-butyl (4S)-5-amino-4-[4-[tert-butyl(dimethyl)silyl]oxy-1-oxo-isoindolin-2-yl]-5-oxo-pentanoate

: 1560678-63-8
(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / methanol / 15 - 25 °C

2: potassium carbonate / N,N-dimethyl-formamide / 25 - 50 °C

3: benzenesulfonic acid / acetonitrile / Dean-Stark; Inert atmosphere

4: hydrogenchloride; sodium hydrogencarbonate / water; acetic acid methyl ester / 15 - 25 °C / Inert atmosphere

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; benzenesulfonic acid; In methanol; acetic acid methyl ester; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 359629-73-5
3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-benzoic acid methyl ester

: 1560678-63-8
(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 45 - 50 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / methanol / 15 - 25 °C

3: potassium carbonate / N,N-dimethyl-formamide / 25 - 50 °C

4: benzenesulfonic acid / acetonitrile / Dean-Stark; Inert atmosphere

5: hydrogenchloride; sodium hydrogencarbonate / water; acetic acid methyl ester / 15 - 25 °C / Inert atmosphere

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; benzenesulfonic acid; In methanol; acetic acid methyl ester; water; N,N-dimethyl-formamide; acetonitrile;