N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide

Base Information

Chemical Name:N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide
CAS No.:1035572-33-8
Molecular Formula:C₂₄H₂₂Cl₂N₂O₅
Molecular Weight:489.355
Hs Code.:

Synonyms:N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide

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Chemical Property of N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide

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Technology Process of N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide

There total 7 articles about N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035572-31-6
{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}aceticacid

: 100-46-9
benzylamine

: 1035572-33-8
N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/jm500378a

Reference yield:

: 100868-46-0
3,5-dichloro-4-picoline

: 1035572-33-8
N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 0 °C

2.1: boron trichloride / dichloromethane / 2 h / 20 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 °C

4.1: lithium hydroxide / methanol; water / 1 h / 20 °C

4.2: pH 1

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With boron trichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500378a

Reference yield:

: 1035571-47-1
{6-[2-(3,5-dichloropyridin-4-yl)-acetyl]-2,3-dimethoxyphenoxy}acetic acid ethyl ester

: 1035572-33-8
N-benzyl-2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / methanol; water / 1 h / 20 °C

1.2: pH 1

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500378a