3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate

Base Information

Chemical Name:3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate
CAS No.:1202013-28-2
Molecular Formula:C₁₇H₁₃ClFN₃O₄
Molecular Weight:377.759
Hs Code.:

Synonyms:3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate

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Chemical Property of 3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate

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Technology Process of 3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate

There total 7 articles about 3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202013-26-0
3-(3-chloro-4-fluorobenzyl)-5-methoxypyrido[3,4-d]pyrimidin-4(3H)-one-7-oxide

: 108-24-7
acetic anhydride

: 1202013-28-2
3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate

Guidance literature:: 3-(3-chloro-4-fluorobenzyl)-5-methoxypyrido[3,4-d]pyrimidin-4(3H)-one-7-oxide; acetic anhydride; at 130 ℃; for 0.333333h; Microwave irradiation;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 50720-12-2
3-bromo-5-methoxypyridine

: 1202013-28-2
3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 72 h / 90 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -25 °C

2.2: -78 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: ethanol / 48 h / Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

6.1: peracetic acid; sodium acetate; acetic acid / 12 h / 20 °C

7.1: 0.33 h / 130 °C / Microwave irradiation

With peracetic acid; n-butyllithium; sodium acetate; caesium carbonate; acetic acid; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: pyrido[3,4-d]pyrimidin-4(3H)-one

: 1202013-28-2
3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2: peracetic acid; sodium acetate; acetic acid / 12 h / 20 °C

3: 0.33 h / 130 °C / Microwave irradiation

With peracetic acid; sodium acetate; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;