5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine

Base Information

• Chemical Name: 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine
• CAS No.: 650629-18-8
• Molecular Formula: C₁₉H₂₀FN₃O₈
• Molecular Weight: 437.382
• Mol file: 650629-18-8.mol

Synonyms:5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine

Chemical Property of 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine

There total 5 articles about 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-methyl-2-(2-nitrophenyl)propanoic acid (126802-52-6) + 5-Fluoro-3'-deoxyuridine (18829-83-9) → 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine (650629-18-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; at 20 ℃; for 18h;

DOI:10.1016/S0968-0896(03)00426-7

Reference yield:

5'-(3-(2-nitrophenyl)-2,2-dimethylpropionyl)-2'-deoxy-5-fluorouridine (650629-20-2) → 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine (650629-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / Pd/C / methanol / atmospheric pressure

2: 53 percent / triphenylphosphine; diethyl azodicarboxylate / dioxane / 18 h / 20 °C

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In 1,4-dioxane; methanol; 2: Mitsunobu reaction;

DOI:10.1016/S0968-0896(03)00426-7

Reference yield:

5'-[(2-nitrophenyl)acetyl]-2'-deoxy-5-fluorouridine (650629-17-7) → 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine (650629-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / Pd/C / methanol / atmospheric pressure

2: aq. phosphate buffer / 37 °C / pH 7.4

3: 53 percent / triphenylphosphine; diethyl azodicarboxylate / dioxane / 18 h / 20 °C

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In 1,4-dioxane; methanol; phosphate buffer; 3: Mitsunobu reaction;

DOI:10.1016/S0968-0896(03)00426-7

upstream raw materials:

2-methyl-2-(2-nitrophenyl)propanoic acid

5-Fluoro-3'-deoxyuridine

5'-[(2-aminophenyl)acetyl]-2'-deoxy-5-fluorouridine

5'-[(2-nitrophenyl)acetyl]-2'-deoxy-5-fluorouridine

Downstream raw materials:

3,3-dimethyloxindole

5-Fluoro-3'-deoxyuridine

5'-(3-(2-nitrophenyl)-2,2-dimethylpropionyl)-2'-deoxy-5-fluorouridine

5'-(3-(2-nitrophenyl)propionyl)-2'-deoxy-5-fluorouridine