N⁶-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine

Base Information

• Chemical Name: N⁶-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine
• CAS No.: 122246-39-3
• Molecular Formula: C₁₇H₁₇N₅O₂
• Molecular Weight: 323.354
• Mol file: 122246-39-3.mol

Synonyms:N⁶-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine

Chemical Property of N⁶-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine

There total 1 articles about N⁶-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-diamino-6-nitroquinazoline (7154-34-9) → N6-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine (122246-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney Ni / dimethylformamide / 3 h / 1810.02 Torr / Ambient temperature

2: AcOH

With hydrogen; acetic acid; nickel; In N,N-dimethyl-formamide;

DOI:10.1021/jm980081y

Reference yield:

N6-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine (122246-39-3) → N6-(2,4-dimethoxy-benzyl)-quinazoline-2,4,6-triamine (118291-97-7)

Guidance literature:

With hydrogen; acetic acid; nickel; for 7h; under 1810.02 Torr; Yield given; Ambient temperature;

DOI:10.1021/jm980081y

Reference yield:

N6-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-quinazoline-2,4,6-triamine (122246-39-3) → N6-(2,4-dimethoxy-benzyl)-N6-methyl-quinazoline-2,4,6-triamine

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, AcOH / Raney Ni / 7 h / 1810.02 Torr / Ambient temperature

2: sodium cyanoborohydride, concd. HCl / acetonitrile

With hydrogenchloride; hydrogen; sodium cyanoborohydride; acetic acid; nickel; In acetonitrile;

DOI:10.1021/jm980081y

upstream raw materials:

2,4-diamino-6-nitroquinazoline

Downstream raw materials:

N⁶-(2,4-dimethoxy-benzyl)-quinazoline-2,4,6-triamine