2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide
CAS No.:1423008-10-9
Molecular Formula:C₃₃H₃₃BClN₃O₆S
Molecular Weight:645.972
Hs Code.:

2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

Synonyms:2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

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Chemical Property of 2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

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Technology Process of 2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

There total 17 articles about 2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423008-09-6
6-[N-(4-bromo-3-cyanophenyl)methanesulfonamido]-2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-1-benzofuran-3-carboxamide

: 73183-34-3
bis(pinacol)diborane

: 1423008-10-9
2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 90 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield:

: 1331943-24-8
2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1423008-10-9
2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / water; 1,2-dimethoxyethane / 80 °C / Sealed tube

2: sodium dithionite / water; tetrahydrofuran / 20 °C / Inert atmosphere

3: copper(ll) bromide; 2-Methyl-2-nitropropane / acetonitrile / 0.5 h / 50 °C

4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere; Sealed tube

With sodium dithionite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2-Methyl-2-nitropropane; potassium acetate; potassium carbonate; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; acetonitrile;

Reference yield:

: 1331943-23-7
5-cyclopropyl-2-(4-chlorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylic acid

: 1423008-10-9
2-(4-chlorophenyl)-6-(N-(3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-5-cyclopropyl-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 2 h

2.1: potassium carbonate / water; 1,2-dimethoxyethane / 80 °C / Sealed tube

3.1: sodium dithionite / water; tetrahydrofuran / 20 °C / Inert atmosphere

4.1: copper(ll) bromide; 2-Methyl-2-nitropropane / acetonitrile / 0.5 h / 50 °C

5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere; Sealed tube

With sodium dithionite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2-Methyl-2-nitropropane; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;