N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide

Base Information

Chemical Name:N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide
CAS No.:1228591-34-1
Molecular Formula:C₂₃H₁₄F₄N₄O₂S
Molecular Weight:486.449
Hs Code.:

Synonyms:N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide

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Chemical Property of N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide

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Technology Process of N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide

There total 1 articles about N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1228591-33-0
N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2-[3-(trifluoromethyl)phenyl]acetamide

: 333-20-0
potassium thioacyanate

: 1228591-34-1
N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: N-[5-(4-amino-2-cyanophenoxy)-2-fluorophenyl]-2-[3-(trifluoromethyl)phenyl]acetamide; potassium thioacyanate; With acetic acid; at 20 ℃; for 0.166667h;

With bromine; In acetic acid; at 20 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield: 95.0%

: 1228591-34-1
N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1228591-30-7
N?(7-cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 55.0%

: 1228591-34-1
N-{5-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]-2-fluorophenyl}-2-[3-(trifluoromethyl)phenyl]acetamide

: 2-(2-(2-(2-oxo-2-(thiazol-2-ylamino)ethoxy)ethoxy)ethoxy)acetic acid

: C₃₄H₂₇F₄N₅O₈S₂

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00499