N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl-5-phenyl-D-norvaline

Base Information

Chemical Name:N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl-5-phenyl-D-norvaline
CAS No.:159635-47-9
Molecular Formula:C₂₀H₃₀N₂O₅
Molecular Weight:378.469
Hs Code.:
DSSTox Substance ID:DTXSID801160601

Synonyms:SCHEMBL5226651;DTXSID801160601;N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl-5-phenyl-D-norvaline;159635-47-9

Suppliers and Price of N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl-5-phenyl-D-norvaline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl-5-phenyl-D-norvaline

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:378.21547206
Heavy Atom Count:27
Complexity:519

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(C)(C)C(=O)NC(CCCC1=CC=CC=C1)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](CCCC1=CC=CC=C1)C(=O)O

Technology Process of N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl-5-phenyl-D-norvaline

There total 8 articles about N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl-5-phenyl-D-norvaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₂₂H₃₄N₂O₅

: 159635-47-9
(R)-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; ethanol; at 5 - 10 ℃; for 2.16667h;

Reference yield:

: 36061-08-2,2046-19-7
(2R)-2-amino-5-phenylpentanoic acid

: 103290-07-9
2-tert-butoxycarbonylamino-2-methyl-propionic acid-2,5-dioxo-pyrrolidin-1-yl ester

: 159635-47-9
(R)-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoic acid

Guidance literature:: With triethylamine; In 1,4-dioxane; water;

Reference yield:

: 156130-68-6
2-(tert-butoxycarbonylamino)-5-phenyl-D-pentanoic acid

: 159635-47-9
(R)-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: EDC, DMAP / CH₂Cl₂ / 0 °C

2: HCl / ethyl acetate / 0 °C

3: HOBt, EDC / Ambient temperature

4: H₂ / Pd/C

With hydrogenchloride; dmap; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(98)00238-8