156130-68-6

Usage

Uses

Used in Chemical Research:
BOC-D-2-AMINO-5-PHENYL-PENTANOIC ACID DCHA SALT is used as a building block for the synthesis of peptides and other organic molecules, contributing to the advancement of chemical research.
Used in Pharmaceutical Research:
In the pharmaceutical industry, BOC-D-2-AMINO-5-PHENYL-PENTANOIC ACID DCHA SALT is utilized as a key component in the development of new drugs. Its versatility in reacting with various functional groups allows for the creation of innovative and effective pharmaceutical compounds.
Used in Drug Synthesis:
BOC-D-2-AMINO-5-PHENYL-PENTANOIC ACID DCHA SALT is employed as a crucial intermediate in the synthesis of complex drug molecules, facilitating the discovery and production of novel therapeutic agents.

Upstream product

• 206360-08-9 2-tert-butoxycarbonylamino-5-phenyl-pentanoic acid ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1400695-38-6 tert-butyl ((2R,3R)-1,2-dihydroxy-6-phenylhexan-3-yl)carbamate 
• 62777-26-8 D-N-acetyl-2-amino-5-phenylpentanoic acid 
• 52161-73-6 2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester 
• 108019-30-3 DL-N-acetyl-2-amino-5-phenylpentanoic acid 
• 637-59-2 1-Bromo-3-phenylpropane 

Downstream Products

• 1400695-41-1 (R)-methyl 2-((tert-butoxycarbonyl)amino)-5-phenylpentanoate 
• 210481-93-9 (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester 
• 210481-94-0 (2-{4-[(R)-2-(2-tert-Butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoyl]-piperazin-1-yl}-phenylsulfamoyl)-acetic acid methyl ester 
• 210481-92-8 [1-Methyl-1-((R)-4-phenyl-1-{4-[2-(propane-2-sulfonylamino)-phenyl]-piperazine-1-carbonyl}-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of allylic amines: Via hydroamination of allenes with benzophenone imine

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier.

Organocatalytic one-pot oxidative cleavage of terminal diols to dehomologated carboxylic acids

The organocatalytic one-pot oxidative cleavage of terminal 1,2-diols to one-carbon-unit-shorter carboxylic acids is described. The combination of 1-Me-AZADO (cat.), NaOCl (cat.), and NaClO2 caused smooth one-pot oxidative cleavage under mild conditions. A broad range of substrates including carbohydrates and N-protected amino diols were converted without epimerization. Terminal triols and tetraols respectively underwent cleavage of their C-2 and C-3 moieties to afford their corresponding two- and three-carbon-unit-shorter carboxylic acids.

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-d-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the phenyl ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-d-Ser-AIB derivative.

GROWTH HORMONE SECRETAGOGUES

This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

Spiro piperidines and homologs promote release of growth hormone

There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.