N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide

Base Information

Chemical Name:N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide
CAS No.:1430725-29-3
Molecular Formula:C₂₄H₁₈F₂N₆O
Molecular Weight:444.443
Hs Code.:

Synonyms:N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide

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Chemical Property of N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide

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Technology Process of N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide

There total 15 articles about N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1430729-04-6
5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-amine

: 802294-64-0,79-09-4
propionic acid

: 1430725-29-3
N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide

Guidance literature:: With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 364-75-0
1-fluoro-4-iodo-2-nitro-benzene

: 1430725-29-3
N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

2: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C

3: 0.5 h / 100 °C

4: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C

5: acetic acid; iron / 1.16 h / 80 °C

6: 1 h / 80 °C

7: hydrogenchloride / ethanol / 1 h / 80 °C

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 6 h / 20 °C

With hydrogenchloride; potassium fluoride; copper(l) iodide; iron; ammonium chloride; caesium carbonate; acetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430725-29-3
N-(5-(5-(1H-1,2,4-triazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)propionamide

Guidance literature:: Multi-step reaction with 12 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C

7: 0.5 h / 100 °C

8: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C

9: acetic acid; iron / 1.16 h / 80 °C

10: 1 h / 80 °C

11: hydrogenchloride / ethanol / 1 h / 80 °C

12: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 6 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;