5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one

Base Information

Chemical Name:5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one
CAS No.:362483-87-2
Molecular Formula:C₁₇H₂₃ClO₃Si
Molecular Weight:338.906
Hs Code.:

5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5<i>H</i>-furan-2-one

Synonyms:5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one

Chemical Property:

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Technology Process of 5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one

There total 7 articles about 5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53088-68-9
methyl 3-chlorophenylacetate

: 362483-87-2
5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -60 °C

1.2: tetrahydrofuran / 1 h / -60 - 20 °C

2.1: LiOH / methanol; H₂O / 20 h / 20 °C

3.1: 57percent MCPBA / CHCl₃ / 3 h / Heating

4.1: imidazole / dimethylformamide / 12 h / 20 °C

5.1: LDA / tetrahydrofuran / 2 h / -60 °C

5.2: tetrahydrofuran / 0.5 h / -60 - 20 °C

6.1: MCPBA / CHCl₃ / 2 h / 20 °C

With 1H-imidazole; lithium hydroxide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010155x

Reference yield:

: C₂₃H₂₉ClO₃SeSi

: 362483-87-2
5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 2h;
DOI:10.1021/jm010155x

Reference yield:

: 1878-65-5
3-chlorophenylacetic acid

: 362483-87-2
5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-5H-furan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / HCl / 3 h / Heating

2.1: LDA / tetrahydrofuran / 0.5 h / -60 °C

2.2: tetrahydrofuran / 1 h / -60 - 20 °C

3.1: LiOH / methanol; H₂O / 20 h / 20 °C

4.1: 57percent MCPBA / CHCl₃ / 3 h / Heating

5.1: imidazole / dimethylformamide / 12 h / 20 °C

6.1: LDA / tetrahydrofuran / 2 h / -60 °C

6.2: tetrahydrofuran / 0.5 h / -60 - 20 °C

7.1: MCPBA / CHCl₃ / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010155x