(phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide

Base Information

• Chemical Name: (phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide
• CAS No.: 699020-11-6
• Molecular Formula: C₁₉H₃₃NO₃Si
• Molecular Weight: 351.561
• Mol file: 699020-11-6.mol

Synonyms:(phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide

Chemical Property of (phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide

There total 4 articles about (phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-<(benzyloxycarbonyl)amino>pentanol (87905-98-4) + tert-butyldimethylsilyl chloride (18162-48-6) → (phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide (699020-11-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.03.035

Reference yield:

5-hydroxypentylamine (2508-29-4) → (phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide (699020-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / methanol; H₂O / Heating

2: 2.99 g / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; sodium hydrogencarbonate; In methanol; dichloromethane; water;

DOI:10.1021/jo049759+

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (phenylmethoxy)-N-[5-(1,1,2,2-tetramethyl-1-silapropoxy)pentyl]carboxamide (699020-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / methanol; H₂O / Heating

2: 2.99 g / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; sodium hydrogencarbonate; In methanol; dichloromethane; water;

DOI:10.1021/jo049759+

upstream raw materials:

5-<(benzyloxycarbonyl)amino>pentanol

tert-butyldimethylsilyl chloride

5-hydroxypentylamine

benzyl chloroformate

Downstream raw materials:

(+)-(S,E)-benzyl (4-hydroxy-7-oxooct-5-en-1-yl)carbamate

(2S,3R)-3-hydroxy-2-(2-oxopropyl)piperidine-1-carboxylic acid benzyl ester

(2R,3S)-3-hydroxy-2-(2-oxopropyl)piperidine-1-carboxylic acid benzyl ester