methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

Base Information

Chemical Name:methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate
CAS No.:916493-60-2
Molecular Formula:C₂₈H₂₆N₄O₄S
Molecular Weight:514.605
Hs Code.:

Synonyms:methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

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Chemical Property of methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

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Technology Process of methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

There total 2 articles about methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916489-36-6
methyl 2-((6S,Z)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl)acetate

: 127972-02-5
5-formyl-2-methoxyphenyl boronic acid

: 916493-60-2
methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

Guidance literature:: With potassium fluoride; cesium fluoride; palladium diacetate; johnphos; In tetrahydrofuran; for 18h; Heating / reflux;

Reference yield:

: 202592-23-2
(S)-[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

: 916493-60-2
methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 5 h / 0 - 20 °C

2: potassium fluoride; cesium fluoride / palladium diacetate; johnphos / tetrahydrofuran / 18 h / Heating / reflux

With potassium fluoride; thionyl chloride; cesium fluoride; palladium diacetate; johnphos; In tetrahydrofuran;

Reference yield:

: 916493-60-2
methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

: 75-16-1
methylmagnesium bromide

: methyl (S)-{4-[5'-(1-hydroxyethyl)-2'-methoxybiphenyl-4-yl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

Guidance literature:: methyl (S)-{4-(5'-formyl-2'-methoxybiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate; methylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 0.5h;

With hydrogenchloride; water; In tetrahydrofuran;

With sodium hydrogencarbonate; In chloroform; water;