6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1336965-95-7
Molecular Formula:C₁₉H₁₃ClF₃NO₃
Molecular Weight:395.765
Hs Code.:

Synonyms:6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Chemical Property of 6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Chemical Property:

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Technology Process of 6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 1 articles about 6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 600-18-0
2-Oxobutyric acid

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 13726-14-2
4-chloro-m-anisidine

: 1336965-95-7
6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: 3-Trifluoromethylbenzaldehyde; 4-chloro-m-anisidine; In ethanol; for 1h; Reflux;

2-Oxobutyric acid; In ethanol; for 3h; Reflux;

Reference yield:

: 1336965-95-7
6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 74-88-4
methyl iodide

: 1336965-97-9
methyl 6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: 6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1336965-95-7
6-chloro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 1336965-99-1
methyl 6-chloro-7-(methyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h

1.2: 20 °C

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

3.1: acetonitrile / 3 h / 20 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;