4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

Base Information

Chemical Name:4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione
CAS No.:853109-68-9
Molecular Formula:C₁₇H₁₇FN₄O₂
Molecular Weight:328.346
Hs Code.:

Synonyms:4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

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Chemical Property of 4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

Chemical Property:

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Technology Process of 4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

There total 8 articles about 4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044668-91-8
4-chloro-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

: 452-80-2
2-fluoro-4-methylaniline

: 853109-68-9
4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 - 20 ℃;

Reference yield:

: 2,2-bis(diphenyl-phosphino)-1,1'-binaphthalene

: 1044668-91-8
4-chloro-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

: 452-80-2
2-fluoro-4-methylaniline

: 3375-31-3
palladium diacetate

: 853109-68-9
4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

Guidance literature:: With caesium carbonate; In toluene;

Reference yield:

: 2-acetyl-4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 853109-68-9
4-((2-fluoro-4-methylphenyl)amino)-1,3,8-trimethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; hydrazine hydrate / 1,4-dioxane / 44 h / 70 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / -70 - 20 °C

With hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;