(R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Base Information

• Chemical Name: (R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• CAS No.: 329926-77-4
• Molecular Formula: C₁₁H₇Cl₂F₃N₂O₂S
• Molecular Weight: 359.156
• Mol file: 329926-77-4.mol

Synonyms:(R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Chemical Property of (R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

There total 2 articles about (R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-amino-2,3-dichlorophenyl thiocyanate (7494-03-3) + R-3,3,3-trifluoro-2-hydroxy-2-methylproanoyl chloride → (R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (329926-77-4)

Guidance literature:

With 2,6-di-tert-butyl-pyridine; In dichloromethane; at 20 ℃;

Reference yield:

2,3-dichloroaniline (608-27-5) → (R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (329926-77-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; sodium bromide / methanol / 1 h

2: 2,6-di-tert-butyl-pyridine / dichloromethane / 20 °C

With 2,6-di-tert-butyl-pyridine; bromine; sodium bromide; In methanol; dichloromethane;

Reference yield: 80.0%

(R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (329926-77-4) + 4-iodo-N,N-dimethylbenzamide (24167-53-1) → (R)-N-[2,3-Dichloro-4-{4-(N,N-dimethylcarbamoyl)phenylsulphanyl}phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (329926-74-1)

Guidance literature:

(R)-N-[2,3-Dichloro-4-thiocyanatophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide; With sodium sulfide; In DMF (N,N-dimethyl-formamide); water; at 50 ℃; for 1h;

4-iodo-N,N-dimethylbenzamide; With copper(I) oxide; In DMF (N,N-dimethyl-formamide); water; at 150 ℃; for 4.5h;

upstream raw materials:

4-amino-2,3-dichlorophenyl thiocyanate

2,3-dichloroaniline

Downstream raw materials:

(R)-N-[2,3-Dichloro-4-{4-(N,N-dimethylcarbamoyl)phenylsulphanyl}phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide